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About Us

Mark D. Wewers, MD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-7707

Email: wewers.2@osu.edu

 

Current OSU Appointments

Professor, Pulm,Allergy,Crit Care & Sleep

Professor, COPH -Environmental Health Sci

Physician, FGP-Pulm-Allrgy-CritCare-Sleep

 

Biographical

Dr. Wewers trained in pulmonary medicine under the direction of Dr. Roger C. Bone at the University of Arkansas for Medical Sciences and then completed a 5 year research experience in the Pulmonary Branch of the National Institutes of Health under the guidance of Dr. Ronald G. Crystal. He was recruited to the faculty of the Ohio State University in 1986 where he has been continously supported by extramural funds from the NIH for his work on lung innate immune function since 1989. In 1996 he was named Division Director of Pulmonary and Critical Care Medicine at Ohio State University and Deputy Director of the Davis Heart and Lung Research Institute in 1997 where he served as interim director from 2000-2002. In 2000 he was bestowed the honor of the John A. Prior Professorship. Dr. Wewers has been a frequent external reviewer for the NIH and served as a permanent member of the Lung Biology and Pathology A study section from 1996-2000. He currently serves as Associate Director of the Davis Heart and Lung Research Institute where he is active in graduate programs and directs an NIH T32 training program on the molecular mechanisms of lung inflammation.

Clinical Interest

Emphysema

Alpha 1-antitrypsin deficiency

Lung inflammation

Sepsis

Certifications

1979 - present Board Certification (Diplomate): American Board of Internal Medicine
1982 - present Board Certification (Diplomate): American Board of Internal Medicine
1986 - present Medical License: State Medical Board of Ohio
1989 - present Board Certification (Diplomate): American Board of Internal Medicine
2010 - 2012 ACLS Provider: American Heart Association
 

Chapters in Books

Wewers, M. D.; Bone, R. C.. "Emphysema and Chronic Bronchitis." In Pulmonary Disease Reviews. Edited by Bone, R. C. 229-244. New York, NY: John Wiley and Sons, Inc., January 1982.

Wewers, M. D.; Bone, R. C.. "Diagnostic Procedures." In Pulmonary Disease: Focus on Clinical Diagnosis. Edited by Hiller, F. C.; Wilson, F.; Bone, R. C.. 153-178. Garden City, NY: Medical Examination Publishing Co., January 1983.

Wewers, M. D.; Bone, R. C.. "Flexible Fiberoptic Bronchoscopy." In Pulmonary Disease: Focus on Clinical Diagnosis. Edited by Hiller, C.; Wilson, F.; Bone, R. C.. 174-194. Garden City, NY: Medical Examination Publishing Co., January 1983.

Wewers, M. D.. "Dyspnea and Cirrhosis." In Contemporary Internal Medicine. Edited by Bowen, J.; Mazzaferri, E. M.. 70-81. New York, NY: Plenum Medical Book Co., January 1988.

Wewers, M. D.; Gadek, J. E.. "Proinflammatory Peptides." In The Lung: Scientific Foundations. Edited by Crystal, R. G.; West, J. B.. 91-103. New York, NY: Raven Press, Ltd., January 1991.

Wewers, M. D.. "Cytokines and Macrophages." In Cytokines in Health and Disease. Edited by Remick, D. G.; Kunkel, S. L.. 327-351. New York, NY: Marcel Dekker, Inc., January 1992.

Wewers, M. D.. "Augmentation of Liver Production." In Lung Biology in Health and Disease Volume 88; Alpha 1-antirypsin Deficiency: Biology, Pathogenesis, Clinical Manifestations, Therapy. Edited by Crystal, R. G.. 333-340. New York, NY: Marcell Dekker, Inc., January 1996.

Wewers, M. D.. "Cytokines and Macrophages." In Cytokines in Health & Disease. Edited by Remick/Friedland. Chapter 23: 339-355. New York, NY: Marcel Dekker, Inc., January 1996.

Marsh, C. B.; Wewers, M. D.. "The Pathogenesis of Sepsis: Factors that Modulate the Response to Gram-Negative Bacterial Infection." In Clinics in Chest Medicine. 2 ed. Vol. 17. Edited by Dorinsky, P. M.. 183-197. Philadelphia, PA: W. B. Saunders Co., January 1996.

Wewers, M. D.; Gadek, J. E.; Marsh, C. B.. "Proinflammatory Cytokines." In The Lung: Scientific Foundations. 2nd ed. Edited by Crystal, R. G.; West, J. B.; Barnes, P. J.; Weibel, E. R.. 117-132. New York, NY: Raven Press, Ltd., January 1997.

 

Degrees

1972 B.A., University Of Arkansas

1976 M.D., University Of Arkansas

 

Editorial Activities

present Proceedings of the National Academy of Sciences
present New England Journal of Medicine
present Journal of Biological Chemistry
present Critical Care Medicine
present CHEST
present Blood
present American Journal of Respiratory Cell and Molecular Biology
present American Journal of Respiratory and Critical Care Medicine
present American Journal of Physiology
present Journal of Clinical Investigation
present Infection and Immunity
present Genes and Immunity
present Cytokine
present
present Public Library of Science One
present Journal of Immunological Methods
1999 - 2003 Journal of Immunology
 

Honors

1973 McGuire Scholarship Recipient.
1976 Alpha Omega Alpha.
1998 Unverferth Award for Leadership in Research. Department of Internal Medicine, College of Medicine.
2000 John A. Prior Professorship.
2003 Distinguished Mentor Award. Davis Heart and Lung Research Institute.
2005 America's Best Doctors.
2006 Collaborative Leader Award. Davis Heart and Lung Research Institute.
2007 America's Best Doctors. U.S. News & World Report.
2011 America's Best Doctors.
 

Journal Articles

Hiller, F. C.; Lucas, E. A.; Phillips, J. R.; Wewers, M. D.. "Medical grand rounds: sleep apnea syndrome.." The Journal of the Arkansas Medical Society. Vol. 76, no. 10. (January 1980.): 391-398.

Wewers, M. D.; Hiller, F. C.; Wilson, F. J.; Bone, R. C.. "Haemophilus influenzae infection of an existing lung cyst.." Southern Medical Journal. Vol. 75, no. 6. (January 1982.): 736-737.

Wewers, M. D.; Rennard, S. I.; Hance, A. J.; Bitterman, P. B.; Crystal, R. G.. "Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1.." The Journal of Clinical Investigation. Vol. 74, no. 6. (January 1984.): 2208-2218.

Straus, S.D.; Fells, G.A.; Wewers, M.D.; Courtney, M.; Tessier, L.H.; Tolstoshev, P.; Lecocq, J.P.; Crystal, R.G.. "Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency.." Biochemical and Biophysical Research Communications. Vol. 130, no. 3. (January 1985.): 1177-1184.

Pelham, F.; Wewers, M. D.; Crystal, R. G.; Buist, S. A.; Janoff, A.. "Urinary excretion of desmosine (elastin crosslinks) in subjects with PiZZ alpha-1-antitrypsin deficiency, a phenotype associated with hereditary predisposition to pulmonary emphysema." American Review of Respiratory Disease. Vol. 132, (January 1985.): 821-823.

Wewers, M.D.; Gadek, J.E.; Keogh, B.A.; Fells, G. A.; Crystal, R. G.. "Evaluation of danazol therapy for patients with PiZZ alpha-1-antitrypsin deficiency.." The American Review of Respiratory Disease. Vol. 134, no. 3. (January 1986.): 476-480.

Bitterman, P. B.; Wewers, M. D.; Rennard, S. I.; Adelberg, S.; Crystal, R. G.. "Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators.." The Journal of Clinical Investigation. Vol. 77, no. 3. (January 1986.): 700-708.

Bitterman, P. B.; Rennard, S. I.; Keogh, B. A.; Wewers, M. D.; B. Adelberg, S; Crystal, R. G.. "Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members.." The New England Journal of Medicine. Vol. 314, no. 21. (January 1986.): 1343-1347.

Wewers, M.D., Gadek, J.E.. "The protease theory of emphysema." Annals of Internal Medicine. Vol. 107, (January 1987.): 761-763.

Wewers, M. D.; Saltini, C.; Sellers, S.; Tocci, M. J.; Bayne, E. K.; Schmidt, J. A.; Crystal, R. G.. "Evaluation of alveolar macrophages in normals and individuals with active pulmonary sarcoidosis for the spontaneous expression of the interleukin-1 beta gene.." Cellular Immunology. Vol. 107, no. 2. (January 1987.): 479-488.

Wewers, M. D.; Gadek, J. E.. "The protease theory of emphysema.." Annals of Internal Medicine. Vol. 107, no. 5. (January 1987.): 761-763.

Wewers, M. D.; Casolaro, M. A.; Sellers, S. E.; Swayze, S. C.; McPhaul, K. M.; Wittes, J. T.; Crystal, R. G.. "Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema.." The New England Journal of Medicine. Vol. 316, no. 17. (January 1987.): 1055-1062.

Wewers, M. D.; Casolaro, M. A.; Crystal, R. G.. "Comparison of alpha-1-antitrypsin levels and antineutrophil elastase capacity of blood and lung in a patient with the alpha-1-antitrypsin phenotype null-null before and during alpha-1-antitrypsin augmentation therapy.." The American Review of Respiratory Disease. Vol. 135, no. 3. (January 1987.): 539-543.

Casolaro, M.A.; Fells, G.; Wewers, M. D.; Pierce, J. E.; Ogushi, F.; Hubbard, R.; Sellers, S.; Forstrom, J.; Lyons, D.; Kawasaki, G.. "Augmentation of lung antineutrophil elastase capacity with recombinant human alpha-1-antitrypsin.." Journal of Applied Physiology (Bethesda, Md. : 1985). Vol. 63, no. 5. (January 1987.): 2015-2023.

Wewers, M.D.; Brantly, M.L.; Casolaro, M.A.; Crystal, R.G.. "Evaluation of tamoxifen as a therapy to augment alpha-1-antitrypsin concentrations in Z homozygous alpha-1-antitrypsin-deficient subjects.." The American Review of Respiratory Disease. Vol. 135, no. 2. (January 1987.): 401-402.

Wewers, M. D.; Herzyk, D. J.; Gadek, J. E.. "Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin.." The Journal of Clinical Investigation. Vol. 82, no. 4. (January 1988.): 1260-1267.

Davis, W. B.; Husney, R. M.; Wewers, M. D.; Herzyk, D. J.; Sagone, A. L.. "Effect of O2 partial pressure on the myeloperoxidase pathway of neutrophils.." Journal of Applied Physiology (Bethesda, Md. : 1985). Vol. 65, no. 5. (January 1988.): 1995-2003.

Bernaudin, J.F.; Yamauchi, K.; Wewers, M. D.; Tocci, M. J.; Ferrans, V. J.; Crystal, R. G.. "Demonstration by in situ hybridization of dissimilar IL-1 beta gene expression in human alveolar macrophages and blood monocytes in response to lipopolysaccharide.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 140, no. 11. (January 1988.): 3822-3829.

Allen, J.N.; Wewers, M.D.. "HIV-associated bronchiolitis obliterans organizing pneumonia.." Chest. Vol. 96, no. 1. (January 1989.): 197-198.

Wewers, M.D.; Herzyk, D. J.; Gadek, J.E.. "Comparison of smoker and nonsmoker lavage fluid for the rate of association with neutrophil elastase.." American Journal of Respiratory Cell and Molecular Biology. Vol. 1, no. 5. (January 1989.): 423-429.

Wewers, M.D.. "Pathogenesis of emphysema. Assessment of basic science concepts through clinical investigation.." Chest. Vol. 95, no. 1. (January 1989.): 190-.

Wewers, M. D.; Herzyk, D. J.. "Alveolar macrophages differ from blood monocytes in human IL-1 beta release. Quantitation by enzyme-linked immunoassay.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 143, no. 5. (January 1989.): 1635-1641.

She, Z. W.; Wewers, M. D.; Herzyk, D. J.; Sagone, A. L.; Davis, W. B.. "Tumor necrosis factor primes neutrophils for hypochlorous acid production.." The American Journal of Physiology. Vol. 257, no. 6 Pt 1. (January 1989.): L338-L345.

Sagone, A. L. Jr; Husney, R.M.; Wewers, M. D.; Herzyk, D. J.; Davis, W. B.. "Effect of dimethylthiourea on the neutrophil myeloperoxidase pathway.." Journal of Applied Physiology (Bethesda, Md. : 1985). Vol. 67, no. 3. (January 1989.): 1056-1062.

Allen, J.N.; Wewers, M.D.. "Acute myocardial infarction with cardiogenic shock during pregnancy: treatment with intra-aortic balloon counterpulsation.." Critical Care Medicine. Vol. 18, no. 8. (January 1990.): 888-889.

Wewers, M. D.; Rinehart, J. J.; She, Z. W.; Herzyk, D. J.; Hummel, M. M.; Kinney, P. A.; Davis, W. B.. "Tumor necrosis factor infusions in humans prime neutrophils for hypochlorous acid production.." The American Journal of Physiology. Vol. 259, no. 4 Pt 1. (January 1990.): L276-L282.

Anderson, C. L.; Shen, L.; Eicher, D. M.; Wewers, M. D.; Gill, J. K.. "Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes.." The Journal of Experimental Medicine. Vol. 171, no. 4. (January 1990.): 1333-.

Allen, J. N.; Herzyk, D. J.; Wewers, M. D.. "Colchicine has opposite effects on interleukin-1 beta and tumor necrosis factor-alpha production.." The American Journal of Physiology. Vol. 261, no. 4 Pt 1. (January 1991.): L315-.

Herzyk, D. J.; Allen, J. N.; Marsh, C. B.; Wewers, M. D.. "Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing.." Journal of immunology (Baltimore, Md. : 1950). Vol. 149, no. 9. (January 1992.): 3052-.

Allen, J. N.; Herzyk, D. J.; Allen, E. D.; Wewers, M. D.. "Human whole blood interleukin-1-beta production: kinetics, cell source, and comparison with TNF-alpha.." The Journal of Laboratory and Clinical Medicine. Vol. 119, no. 5. (January 1992.): 538-546.

Herzyk, D. J.; Berger, A. E.; Allen, J. N.; Wewers, M. D.. "Sandwich ELISA formats designed to detect 17 kDa IL-1 beta significantly underestimate 35 kDa IL-1 beta.." Journal of Immunological Methods. Vol. 148, no. 1-2. (January 1992.): 243-254.

Wewers, M.D.; Pope, H.A.; Miller, D.K.. "Processing proIL-1 beta decreases detection by a proIL-1 beta specific ELISA but increases detection by a conventional ELISA.." Journal of Immunological Methods. Vol. 165, no. 2. (January 1993.): 269-.

Herzyk, D. J.; Wewers, M. D.. "ELISA detection of IL-1 beta in human sera needs independent confirmation. False positives in hospitalized patients.." The American Review of Respiratory Disease. Vol. 147, no. 1. (January 1993.): 139-.

Diaz, P. T.; Julian, M. W.; Wewers, M. D.; Clanton, T. L.. "Tumor necrosis factor and endotoxin do not directly affect in vitro diaphragm function.." The American Review of Respiratory Disease. Vol. 148, no. 2. (January 1993.): 281-287.

She, Z. W.; Wewers, M. D.; Herzyk, D. J.; Davis, W. B.. "Tumor necrosis factor increases the elastolytic potential of adherent neutrophils: a role for hypochlorous acid.." American Journal of Respiratory Cell and Molecular Biology. Vol. 9, no. 4. (January 1993.): 386-392.

Kindt, G. C.; Moore, S. A.; She, Z. W.; Wewers, M. D.. "Endotoxin priming of monocytes augments Fc gamma receptor cross-linking-induced TNF-alpha and IL-1 beta release.." The American Journal of Physiology. Vol. 265, no. 2 Pt 1. (January 1993.): L178-L185.

Allen, J. N.; Moore, S. A.; Wewers, M. D.. "Taxol enhances but does not induce interleukin-1 beta and tumor necrosis factor-alpha production.." The Journal of Laboratory and Clinical Medicine. Vol. 122, no. 4. (January 1993.): 374-.

Overdahl, M. C.; Wewers, M. D.. "Acute occlusion of a mainstem bronchus by a rapidly expanding foreign body.." Chest. Vol. 105, no. 5. (January 1994.): 1600-1602.

Marsh, C. B.; Pope, H. A.; Wewers, M. D.. "Fc gamma receptor cross-linking down-regulates IL-1 receptor antagonist and induces IL-1 beta in mononuclear phagocytes stimulated with endotoxin or Staphylococcus aureus.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 152, no. 9. (January 1994.): 4604-4611.

Marsh, C. B.; Moore, S. A.; Pope, H. A.; Wewers, M. D.. "IL-1ra suppresses endotoxin-induced IL-1 beta and TNF-alpha release from mononuclear phagocytes.." The American Journal of Physiology. Vol. 267, no. 1 Pt 1. (January 1994.): L39-.

Marsh, C, B; Wewers, M D.. "Cytokine-induced interleukin-1 receptor antagonist release in mononuclear phagocytes.." American journal of respiratory cell and molecular biology. Vol. 10, no. 5. (January 1994.): 521-.

Allen, J. N.; Moore, S. A.; Pope-Harman, A. L.; Marsh, C. B.; Wewers, M. D.. "Immunosuppressive properties of surfactant and plasma on alveolar macrophages.." The Journal of Laboratory and Clinical Medicine. Vol. 125, no. 3. (January 1995.): 356-.

Altenberger, E. A.; Pope, H. A.; Wewers, M. D.. "Detection of soluble type II receptor in the presence of its natural ligand IL-1 beta. Quantification by sandwich ELISA.." Journal of Immunological Methods. Vol. 185, no. 1. (January 1995.): 115-122.

Wewers, M.D.. "Pathogenesis of emphysema: Assessment of basic science concepts through clinical investigation." Chest. Vol. 95, (January 1995.): 190-195.

Knoell, D. L.; Wewers, M. D.. "Clinical implications of gene therapy for alpha 1-antitrypsin deficiency.." Chest. Vol. 107, no. 2. (January 1995.): 535-545.

O'Brien, J. M. Jr.; Wewers, M. D.; Moore, S. A.; Allen, J. N.. "Taxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion. A role for microtubules in the regulation of IL-1 beta production.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 154, no. 8. (January 1995.): 4113-4122.

Marsh, C. B.; Gadek, J.E.; Kindt, G. C.; Moore, S. A.; Wewers, M. D.. "Monocyte Fc gamma receptor cross-linking induces IL-8 production.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 155, no. 6. (January 1995.): 3161-.

Marsh, C. B.; Wewers, M. D.. "The pathogenesis of sepsis. Factors that modulate the response to gram-negative bacterial infection.." Clinics in Chest Medicine. Vol. 17, no. 2. (January 1996.): 183-.

Marsh, C. B.; Anderson, C. L.; Lowe, M. P.; Wewers, M. D.. "Monocyte IL-8 release is induced by two independent Fc gamma R- mediated pathways.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 157, no. 6. (January 1996.): 2632-2637.

Pue, C. A.; Mortensen, R. F.; Marsh, C. B.; Pope, H. A.; Wewers, M. D.. "Acute phase levels of C-reactive protein enhance IL-1 beta and IL-1ra production by human blood monocytes but inhibit IL-1 beta and IL-1ra production by alveolar macrophages.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 156, no. 4. (January 1996.): 1594-1600.

Brown, E. A.; Dare, H. A.; Marsh, C. B.; Wewers, M. D.. "The combination of endotoxin and dexamethasone induces type II interleukin 1 receptor (IL-1r II) in monocytes: a comparison to interleukin 1 beta (IL-1 beta) and interleukin 1 receptor antagonist (IL-1ra).." Cytokine. Vol. 8, no. 11. (January 1996.): 828-.

Allen, J. N.; Liao, Z; Wewers, M. D; Altenberger, E. A; Moore, S. A; Allen, E. D. "Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia.." The Journal of Allergy and Clinical Immunology. Vol. 97, no. 6. (January 1996.): 1366-1374.

Ralston, D. R.; Marsh, C. B.; Lowe, M. P.; Wewers, M. D.. "Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.." The Journal of Clinical Investigation. Vol. 100, no. 6. (January 1997.): 1416-1424.

Allen, J. N.; Moore, S. A.; Liao, Z.; Wewers, M. D.. "Changes in mononuclear phagocyte microtubules after endotoxin stimulation. I. Changes in microtubule stability.." American Journal of Respiratory Cell and Molecular Biology. Vol. 16, no. 2. (January 1997.): 119-126.

Allen, J. N.; Moore, S. A.; Jurist, U.A.; Liao, Z.; Wewers, M. D.. "Changes in mononuclear phagocyte microtubule stbility and composition after endotoxin stimulation: ll. Changes in microtubule stability." American Journal of Respiratory Cell and Molecular Biology. Vol. 16, (January 1997.): 127-132.

Marsh, C. B.; Wewers, M. D.; Tan, L. C.; Rovin, B. H.. "Fc(gamma) receptor cross-linking induces peripheral blood mononuclear cell monocyte chemoattractant protein-1 expression: role of lymphocyte Fc(gamma)RIII.." Journal of immunology (Baltimore, Md. : 1950). Vol. 158, no. 3. (January 1997.): 1078-.

Wewers, M.D.; Marsh, C. B.. "Role of antibody in transplant vascular sclerosis: a hypothesis." Transplant Immunology. Vol. 5, (January 1997.): 283-288.

Wewers, M. D.; Marsh, C. B.. "Role of the antibody in the pathogenesis of transplant vascular sclerosis: a hypothesis.." Transplant Immunology. Vol. 5, no. 4. (January 1997.): 283-288.

Wewers, M. D.; Dare, H. A.; Winnard, A. V.; Parker, J. M.; Miller, D. K.. "IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 159, no. 12. (January 1997.): 5964-.

Marsh, C. B.; Lowe, M. P.; Rovin, B. H.; Parker, J. M.; Liao, Z.; Knoell, D. L.; Wewers, M D.. "Lymphocytes produce IL-1beta in response to Fcgamma receptor cross-linking: effects on parenchymal cell IL-8 release.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 160, no. 8. (January 1998.): 3942-3948.

Knoell, D. L.; Ralston, D. R.; Coulter, K. R.; Wewers, M. D.. "Alpha 1-antitrypsin and protease complexation is induced by lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha in monocytes.." American Journal of Respiratory and Critical Care Medicine. Vol. 157, no. 1. (January 1998.): 246-.

Wewers, M. D.; Diaz, P. T.; Wewers, M. E.; Lowe, M. P.; Nagaraja, H. N.; Clanton, T. L.. "Cigarette smoking in HIV infection induces a suppressive inflammatory environment in the lung.." American Journal of Respiratory and Critical Care Medicine. Vol. 158, no. 5 Pt 1. (January 1998.): 1543-1549.

Marsh, C. B.; Pomerantz, R. P.; Parker, J. M.; Winnard, A. V.; Mazzaferri, E. L. Jr.; Moldovan, N.; Kelley, T. W.; Beck, E.; Wewers, M. D.. "Regulation of monocyte survival in vitro by deposited IgG: role of macrophage colony-stimulating factor.." Journal of immunology (Baltimore, Md. : 1950). Vol. 162, no. 10. (January 1999.): 6217-.

Diaz, P. T.; King, M. A.; Pacht, E. R.; Wewers, M. D.; Gadek, J. E.; Neal, D.; Nagaraja, H. N.; Drake, J.; Clanton, T. L.. "The pathophysiology of pulmonary diffusion impairment in human immunodeficiency virus infection.." American Journal of Respiratory and Critical Care Medicine. Vol. 160, no. 1. (January 1999.): 272-.

Wewers, M. D.; Winnard, A. V.; Dare, H. A.. "Endotoxin-stimulated monocytes release multiple forms of IL-1 beta, including a proIL-1 beta form whose detection is affected by export.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 162, no. 8. (January 1999.): 4858-4863.

Coulter, K. R.; Wewers, M. D.; Lowe, M. P.; Knoell, D. L.. "Extracellular regulation of interleukin (IL)-1beta through lung epithelial cells and defective IL-1 type II receptor expression.." American Journal of Respiratory Cell and Molecular Biology. Vol. 20, no. 5. (January 1999.): 964-975.

Fahy, R. J.; Doseff, A. I.; Wewers, M. D.. "Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 163, no. 4. (January 1999.): 1755-1762.

Diaz, P. T.; King, M. A.; Pacht, E. R.; Wewers, M. D.; Gadek, J. E.; Nagaraja, H. N.; Drake, J.; Clanton, T. L.. "Increased susceptibility to pulmonary emphysema among HIV-seropositive smokers.." Annals of Internal Medicine. Vol. 132, no. 5. (January 2000.): 369-.

Coulter, K. R.; Allen, E. D.; Hart, J.; Wewers, M. D.; Castile, R. G.; Knoell, D. L.. "Induction of interleukin-8 release by lung epithelium with cystic fibrosis epithelial lining fluid is marginally affected by inhibitors of interleukin-1beta.." Pharmacotherapy. Vol. 20, no. 1. (January 2000.): 64-74.

Diaz, P.T.; King, E.R.; Wewers, M. D.; Gadek, J. E.; Neal, D.; Drake. J.; Clanton, T. L.. "HIV infection increases susceptibility to smoking-induced emphysema." Chest. Vol. 117, (January 2000.): 285S-.

Cooper, M. A.; Fehniger, T. A.; Ponnappan, A.; Mehta, V.; Wewers, M. D.; Caligiuri, M. A. "Interleukin-1beta costimulates interferon-gamma production by human natural killer cells.." European Journal of Immunology. Vol. 31, no. 3. (January 2001.): 792-801.

Swaan, P. W.; Knoell, D. L.; Helsper, F.; Wewers, M. D.. "Sequential processing of human ProIL-1beta by caspase-1 and subsequent folding determined by a combined in vitro and in silico approach.." Pharmaceutical Research. Vol. 18, no. 8. (January 2001.): 1083-1090.

Fahy, R. J.; Diaz, P. T.; Hart, J.; Wewers, M. D.. "BAL and serum IgG levels in healthy asymptomatic HIV-infected patients.." Chest. Vol. 119, no. 1. (January 2001.): 196-203.

Mehta, V. B.; Hart, J.; Wewers, M. D.. "ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage.." The Journal of Biological Chemistry. Vol. 276, no. 6. (January 2001.): 3820-.

Crouser, E. D.; Julian, M. W.; Joshi, M. S.; Bauer, J. A.; Wewers, M. D.; Hart, J. M.; Pfeiffer, D. R.. "Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia.." Critical Care Medicine. Vol. 30, no. 12. (January 2002.): 2722-2728.

Coulter, K. R.; Doseff, A. I.; Sweeney, P.; Wang, Y.; Marsh, C. B.; Wewers, M. D.; Knoell, D. L.. "Opposing effect by cytokines on Fas-mediated apoptosis in A549 lung epithelial cells.." American Journal of Respiratory Cell and Molecular Biology. Vol. 26, no. 1. (January 2002.): 58-66.

Tridandapani, S.; Siefker, K.; Teillaud, J.; Carter, J.; Wewers, M. D.; Anderson, C. L.. "Regulated expression and inhibitory function of Fcgamma RIIb in human monocytic cells.." The Journal of Biological Chemistry. Vol. 277, no. 7. (January 2002.): 5082-5089.

Diaz, P. T.; Wewers, M. D.; Pacht, E.; Drake, J.; Nagaraja, H. N.; Clanton, T. L.. "Respiratory Symptoms Among HIV-Seropositive Individuals." Chest. Vol. 123, no. 6. (January 2003.): 1977-1982.

Doseff, A. I.; Baker, J. H. Jr.; Bourgeois, T. A.; Wewers, M. D.. "Interleukin-4-induced apoptosis entails caspase activation and suppression of extracellular signal-regulated kinase phosphorylation.." American Journal of Respiratory Cell and Molecular Biology. Vol. 29, no. 3 Pt 1. (January 2003.): 367-.

Fahy, R. J.; Lichtenberger, F.; McKeegan, C. B.; Nuovo, G. J.; Marsh, C. B.; Wewers, M. D.. "The acute respiratory distress syndrome: a role for TGF-B1." American Journal of Respiratory Cell and Molecular Biology. Vol. 28(4), (January 2003.): 499-503.

Spragg, R. G.; Lewis, J. F.; Wurst, W.; Hafner, D.; Baughman, R. P.; Wewers, M. D.; Marsh, J. J.. "Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant.." American Journal of Respiratory and Critical Care Medicine. Vol. 167, no. 11. (January 2003.): -.

Diaz, P. T.; Wewers, M. D.; King, M.; Wade, J.; Hart, J.; Clanton, T. L.. "Regional differences in emphysema scores and BAL glutathione levels in HIV-infected individuals.." Chest. Vol. 126, no. 5. (January 2004.): 1439-1442.

Fang, H.; Pengal, R. A.; Cao, X.; Ganesan, L. P.; Wewers, M. D.; Marsh, C. B.; Tridandapani, S.. "Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 173, no. 1. (January 2004.): 360-366.

Crouser, E. D.; Julian, M. W.; Huff, J. E.; Joshi, M. S.; Bauer, J. A.; Gadd, M. E.; Wewers, M. D.; Pfeiffer, D. R.. "Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia.." Critical Care Medicine. Vol. 32, no. 2. (January 2004.): 478-488.

Wewers,M,D. "IL-1 beta: An endosomal exit." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 101, no. 28. (July 2004.): 10241-10242.

Wewers, M. D.. "IL-1beta: an endosomal exit.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 101, no. 28. (January 2004.): 10241-10242.

Wewers, M. D.. "Alpha 1-antitrypsin Deficiency: More than a Protease Imbalance?." Chest. Vol. 125, (January 2004.): 1607-1609.

Kim, H.; Hart, J.; Knatz, N.; Hall, M. W.; Wewers, M. D.. "JAK3 downregulates LPS-induced ICE activation by autocrine IL-10." Journal of Immunology. Vol. 172, (January 2004.): 4948-4955.

Elssner, A.; Duncan, M.; Gavrilin, M.; Wewers, M. D.. "A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 172, no. 8. (January 2004.): -.

Elssner, A.; Doseff, A. I.; Duncan, M.; Kotur, M.; Wewers, M. D.. "IL-16 is constitutively present in peripheral blood monocytes and spontaneously released during apoptosis.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 172, no. 12. (January 2004.): 7721-7725.

Elssner, A.; Carter, J. E.; Yunger, T. M.; Wewers, M. D.. "HIV-1 infection does not impair human alveolar macrophage phagocytic function unless combined with cigarette smoking.." Chest. Vol. 125, no. 3. (January 2004.): 1071-1076.

Wewers, M. D.; Lemeshow, S.; Lehman, A.; Clanton, T. L.; Diaz, P. T.. "Lung CD4 lymphocytes predict survival in asymptomatic HIV infection.." Chest. Vol. 128, no. 4. (January 2005.): 2262-2267.

Fahy, R. J.; Wewers, M. D.. "Pulmonary defense and the human cathelicidin hCAP18/LL37." Immunologic Research. Vol. 1(2), (January 2005.): 75-89.

Voss, O. H.; Kim, S.; Wewers, M. D.; Doseff, A. I.. "Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3.." The Journal of Biological Chemistry. Vol. 280, no. 17. (January 2005.): 17371-17379.

Parsa, K. V. L.; Ganesan, L. P.; Rajaram, M. V. S.; Gavrilin, M. A.; Balagopal, A.; Mohapatra, N. P.; Wewers, M. D.; Schlesinger, L. S.; Gunn, J. S.; Tridandapani, S.. "Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP.." PLoS Pathogens. Vol. 2, no. 7. (January 2006.): e71-.

Sarkar,Anasuya; Hall,Mark,W; Exline,Matthew; Hart,Judy; Knatz,Nina; Gatson,Na,Tosha; Wewers,Mark,D. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1 beta and interleukin-18." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. Vol. 174, no. 9. (November 2006.): 1003-1010.

Sarkar, A.; Hall, M. W.; Exline, M. C.; Hart, J.; Knatz, N.; Gatson, N. T.; Wewers, M. D.. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.." American Journal of Respiratory and Critical Care Medicine. Vol. 174, no. 9. (January 2006.): -.

Sarkar, A.; Duncan, M.; Hart, J.; Hertlein, E.; Guttridge, D. C; Wewers, M. D.. "ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions.." Journal of Immunology (Baltimore, Md. : 1950). Vol. 176, no. 8. (January 2006.): 4979-4986.

Magalang, U. J.; Rajappan, R.; Hunter, M. G.; Kutala, V. K.; Kuppusamy, P.; Wewers, M. D.; Marsh, C. B.; Parinandi, N. L.. "Adiponectin inhibits superoxide generation by human neutrophils.." Antioxidants & Redox Signaling. Vol. 8, no. 11-12. (January 2006.): 2179-2186.

Gavrilin, M. A.; Bouakl, I. J.; Knatz, N. L.; Duncan, M. D.; Hall, M. W.; Gunn, J. S.; Wewers, M. D.. "Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 1. (January 2006.): 141-146.

Nicholas, C.; Batra, S.; Vargo, M. A.; Voss, O. H.; Gavrilin, M. A.; Wewers, M. D.; Guttridge, D.C.; Grotewold, E.; Doseff, A. I.. "Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kB through the suppression of p65 phosphorylation." Journal of Immunology. (January 2007.): -.

Seshadri, S.; Duncan, M. D.; Hart, J. M.; Gavrilin, M. A.; Wewers, M.D.. "Pyrin levels in human monocytes and monocyte derived macrophages modify IL-1ß processing and release." Journal of Immunology. (January 2007.): -.

Hall, M. W.; Gavrilin, M. A.; Knatz, N. L.; Duncan, M. D.; Fernandez, S. A.; Wewers, M. D.. "Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome.." Pediatric Research. Vol. 62, no. 5. (January 2007.): -.

Fahy, R.J.; Exline, M.C.; Gavrilin, M.A.; Bhatt, N.Y.; Besecker, B.Y.; Sarkar, A.; Hollyfield, J.L.; Duncan, M.D.; Nagaraja, H.N.; Knatz, N.L.; Hall, M.; Wewers, M.D.. "Inflammasome mRNA expression in human monocytes during early septic shock." American Journal of Respiratory and Critical Care Medicine. Vol. 177, no. 9. (January 2008.): 983-988.

Crouser E. D.; Exline M. C.; Knoell, D. L.; Wewers, M. D.. "Sepsis: links between pathogen sensing and organ damage." Current Pharmaceutical Design. Vol. 14, no. 19. (January 2008.): 1840-1852.

Butchar, J. P.; Cremer, T. J.; Clay, C. D.; Gavrilin, M. A.; Wewers, M. D.; Marsh, C. B.; Schlesinger, L. S.; Tridandapani, S.. "Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion." PLoS ONE. Vol. 3, no. 8. (August 2008.): e2924-.

Raices, R. M.; Kannan, Y.; Sarkar, A.; Bellamkonda-Athmaram, V.; Wewers, M. D.. "A synergistic role for IL-1beta and TNFalpha in monocyte-derived IFNgamma inducing activity." Cytokine. Vol. 44, no. 2. (November 2008.): 234-241.

Sarkar,Anasuya; Mitra,Srabani; Mehta,Sonya; Raices,Raquel; Wewers,Mark,D. "Monocyte Derived Microvesicles Deliver a Cell Death Message via Encapsulated Caspase-1." PLOS ONE. Vol. 4, no. 9. (September 2009.): e7140-.

Crouser, E.D.; Culver, D. A.; Knox, K.S.; Julian, M.W.; Shao, G.; Abraham, S.; Liyanarachchi, S.; Macre, J.E.; Wewers, M.D.; Gavrilin, M. A.; Ross, P.; Abbas, A.; Eng, C.. "Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis." American Journal of Respiratory and Critical Care Medicine. Vol. 179, no. 10. (January 2009.): 929-938.

Crouser, E. D.; Shao, G.; Julian, M. W.; Macre, J. E.; Shadel, G. S.; Tridandapani, S.; Huang, Q.; Wewers, M. D.;. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." Critical Care Medicine. Vol. 37, no. 6. (January 2009.): 2000-2009.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nirc4/Ipaf inflammasome restricts Legionella pneumophila infection." PLoS Pathogens. Vol. 5, no. 4. (April 2009.): e1000361-.

Seshadri, S.; Kannan, Y.; Mitra, S.; Parker-Barnes, J.; Wewers, M. D.. "MAIL Regulates Human Monocyte IL-6 Production." Journal of Immunology. Vol. 183, no. 8. (January 2009.): 5358-5368.

Raices, R.M.; Kannan, Y.; Bellamkonda-Athmaram, V.; Seshadri, S.; Wang, H.; Guttridge, D.C.; Wewers, M.D.. "A novel role for IkappaB zeta in the regulation of IFN gamma production." PLoS One. Vol. 4, no. 8. (January 2009.): e6776-.

Akhter, A.; Gavrilin, M. A.; Frantz, L.; Washington, S.; Ditty, C.; Limoli, D.; Day, C.; Sarkar, A.; Newland, C.; Butchar, J.; Marsh, C. B.; Wewers, M. D.; Tridandapani, S.; Kanneganti, T.; Amer, A. O.. "Caspase-7 Activation by the Nlrc4/ipaf Inflammasome Restricts Legionella pneumophila Infection." PLoS Pathogens. Vol. 5, no. 4. (January 2009.): Article No.: e1000361-.

Sarkar, A.; Mitra, S.; Mehta, S.; Raices, R.; Wewers, M. D.. "Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1." PLoS One. Vol. 4, no. 9. (January 2009.): e7140-.

Gavrilin, M. A.; Mitra, S.; Seshadri, S.; Nateri, J.; Berhe, F.; Hall, M. W.; Wewers, M. D.. "Pyrin critical to macrophage IL-1beta response to Francisella challenge." Journal of Immunology. Vol. 182, no. 12. (January 2009.): 7982-7989.

Wewers, M.D.; Sarkar, A.. "P2x(7) receptor and macrophage function." Purinergic Signalling. Vol. 5, no. 2. (January 2009.): 189-195.

Crouser ED, Shao G, Julian MW, Macre JE, Shadel GS, Tridandapani S, Huang Q, Wewers MD. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." Critical Care Medicine. Vol. 37, no. 6. (June 2009.): 2000-2009.

Lamkanfi M, Sarkar A, Vitari AC, Amer A, Wewers MD, Tracey KJ, Kanneganti T-D, Dixit VM. "Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia." Journal of Immunology. Vol. 185, (January 2010.): 4385-4392.

Miao EA, Leaf IA, Treuting P, Mao DP, Dors M, Sarkar A, Wewers MD, Aderem A. "Caspase-1 induced pyroptosis clears intracellular bacteria independent of IL-1Beta/IL-18 in vivo." Nature Immunology. Vol. 11, no. 12. (January 2010.): 1136-1142.

Zakharova, E.; Grandhi, J.; Wewers, M. D.; Gavrilin, M. A.. "Mycoplasma suppression of THP-1 cell TLR responses is corrected with antibiotics." PLoS One. Vol. 5, no. 3. (January 2010.): Article No.: e9900-.

Marquardt, D. J.; Knatz, N. L.; Wetterau, L. A.; Wewers, M. D.; Hall, M. W.. "Failure to recover somatotropic axis function is associated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome." Pediatric Critical Care Medicine. Vol. 11, no. 1. (January 2010.): 18-25.

Marquardt DJ, Knatz NL, Wetterau LA, Wewers, MD, Hall MW. "Failure to recove somatotropic asix function is assoicated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome." Pediatric Critical Care Medicine. Vol. 11, no. 1. (January 2010.): 18-25.

Hughes T, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C, Nuovo G, Wei L, Zhang X, Gavrilin MA, Wewers MD, Caligiuri MA. "IL-1Beta selectively expands and sustains IL-22(+) immature human natural killer cells in secondary lymphoid tissue." Immunity. Vol. 32, (January 2010.): 803-814.

Hall MW, Knatz NL, Vetterly C, Tomarello S, Wewers MD, Volk HD, Carcillo JA. "Immunoparalysis and nosocomial infection in children with multiple organ dysfunction." Intensive Care Medicine. Vol. 37, no. 3. (March 2011.): 525-532.

Kannan Y, Yu J, Raices RM, Seshadri S, Wei M, Caligiuri M, Wewers, MD. "ικβζ augments IL-12 and IL-18 mediated IFN-γ production in human NK cells." Blood. Vol. 117, no. 10. (January 2011.): 2855-2863.

Dalia H. Abdelaziz, Mikhail A. Gavrilin, Anwari Akhter, Kyle Caution, Sheetal Kotrange, Arwa Abu Khweek, Basant A. Abdulrahman, Jaykumar Grandhi, Zeinab A. Hassan, Clay Marsh, Mark D. Wewers, Amal O. Amer. "ASC controls legionella pneumophila infection in human monocytes." Journal of Biological Chemistry. Vol. 286, no. 5. (February 2011.): 3203-3208.

 

Reference Works

January 2002 Parker-Barnes, J. M.; Yee, J. F.; Doseff, A. I.; Wewers, M. D.."Isolation and characterization of lkappaBzeta, a new member of the lkappabeta family; interactions with IL-1beta" . : 282
January 2002 Parker-Barnes, J. M.; Yee, J. F.; Doseff, A. I.; Guo, W.; Wewers, M. D.."MAIL gene (1KBzeta) rapidly induced by LPS in monocytes but not in alveolar macrophages" . : A536
January 2002 Fahy, R. J.; Lichtenberger, F.; Wewers, M. D.."Functionally active TGF-Beta 1 is elevated in adult respiratory distress syndrome bronchoalveolar lavage fluid" . : A756
January 2002 Elssner, A.; Duncan, M.; Wewers, M. D.."Anti-serum to interleukin-18 enhances HIV-1 production in monocyte derived macrophages" . : A298
January 2002 Kim, H-J.; Guo, W.; Hart, J.; Wewers, M. D.."Monocyte IL-1Beta converting enzyme activation: kinetics and relationship to IL-1Beta release" . : 187
January 2002 Doseff, A. I.; Sancaktar, O.; Waggoner, A. N.; Wewers, M. D.."Caspase-3 is a phosphoprotein that associates with and is phosphorylated selectively by a PKC isoforms during monocyte lifespan" . : A658
January 2002 Guo, W.; Kim, H-J., Wewers, M. D.."CARDIAK interacts with caspase-1 during endotoxin activation of human monocytes" . : 84
January 2003 Zhang, H.; Wewers, M. D.; Doseff, A. I.; Chalmers, J. J.."A Novel immunomagnetic based technology to quantify the numbers of receptors on human alveolar macrophages" . : A481
January 2003 Fahy, R. J.; Elssner, A.; Wewers, M. D.."The antimicrobial peptide LL-37/hCAP-18 is elevated in early ARDS" . : A759
January 2003 Elssner, A.; Duncan, M.; Wewers, M. D.."The human cathelicidin-derived peptide LL37 induces secretion of IL-1beta via transient ATP release and activation of the P2X7 receptor" . : A759
January 2003 Doseff, A. I.; Voss, O.; Wewers, M. D.."Caspase-3 is a phosphoprotein that associates with and is phosphorylated selectively by a PCK during monocytes lifespan" . : A298
January 2003 Wewers, M. D.; Guo, W.."CARDIAK/RIP2 is expressed in both monocytes and alveolar macrophages and phosphorylates ERK2 after endotoxin challenge" . : A732
January 2003 Knoell, D. L.; Yearsdley, M.; Bao, S. Y.; Diaz, P. T.; Wewers, M. D.; Nuovo, G. J.."HIV-1 infection of human lung epithelium in vitro and in vivo" . : A870
January 2003 Bao, S. Y.; Tripp, R. P.; Gavrilin, M. A.; Diaz, P. T.; Wewers, M. D.; Knoell, D. L.."HIV-1 infection of the Human Lung Epithelium by Free Virus and Cell-to-Cell Contact" .
January 2003 Bao, S. Y.; Gavrilin, M. R.; Diaz, P. T.; Wewers, M. D.; Knoell, D. L.."HIV-1 infects differentiated human lung epithelial cells from the basolateral surface and requires galactosylceramide" . : A196
January 2003 Tandon, R.; Wewers, M. D.."Monocyte induction of lung epithelial cell (A549) IL-8 release is dependent upon cell contact and IL-1beta" . : A644
January 2004 Tridandapani, S.; Fang, H.; Wei, G.; Cao, X.; Pengal R. A.; Wewers, M. D.; Marsh, C. B.; Ostrowski, M. C.."Macrophage inflammatory responses to lipopolysacharide is regulated by the concerted action of lipid phosphatases and kinases" . : C34
January 2004 Knoell, D. L.; Bao, S. Y.; Kim, H-J.; Wewers, M. D.."Modulation of barrier function during death receptor mediated apoptosis in differentiated human lung epithelial cells" . : B55
January 2004 Kim, H-J.; Hart, J.; Knatz, N.; Hall, M. W.; Wewers, M. D.."Janus kinase 3 downregulates LPS induced ICE activation by autocrine IL-10" . : A34
January 2004 Fahy, R. J.; Karavanov, A.; Schneider, G. P.; Wewers, M. D.."Proteomic patterns of BAL fluid in early acute respiratory distress syndrome" . : A44
January 2004 Elssner, A.; Doseff, A.; Duncan, M.; Kotur, M.; Wewers, M. D.."Interleukin-16 is constitutively present in monocytes and released during spontaneous apoptosis" . : A32
May 2004 Hall, M.; Gavrilin, M.; Duncan, M.; Knatz, N.; Wewers, M. D.."Monocyte lkappabeta alpha/NFkappabeta p50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)" San Francisco.
January 2004 Steinhour, E.; Lawson, C.; Hart, J.; Varadharaj, S.; Zweier, J.; Wewers, M. D.; Parinandi, N.."Airborne agricultural dust-induced inflammatory cytokine secretion by respiratory epithelial cells: mechanism of regulation by cell signaling" . : C52
January 2004 Wewers, M. D.; Lemeshow, S.; Lehman, D.; Drake, J.; Bees, T.; Clanton, T. L.; Diaz, P. T.."Lung CD4 counts and hemoglobin levels predict survival in asymptomatic HIV infection" . : D84
January 2004 Sarkar, A.; Hall, M. W.; Wewers, M. D.."Interleukin-1 beta converting enzyme knockout state is protective in experimental murine E-coli sepsis" . : A453
January 2004 Hall, M. W.; Gavrilin, M. A.; Wewers, M. D.."Monocyte lkappabeta alpha/NFkappabetap50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)" . : 330
January 2005 Seshadri, S.; Gavrilin, M. A.; Hart, J.; Duncan, M. D.; Wewers, M. D.."Pyrin expression is suppressed with monocyte to macrophage differentiation" . : A1445
January 2005 Sarkar, A.; Hart, J.; Hertlein, E.; Guttridge, D.; Wewers, M. D.>/b>."ASC is a dual regulator in caspase-1 mediated inflammation and NFkB activation." . : 65
January 2005 Gavrilin, M. A.; Wewers, M. D.."Intracellular infection of monocytes by francisella activates the inflammasome complex" . : 48
January 2005 Bouakl, I. J.; Gavrilin, M. A.; Wewers, M. D.."Intracellular activation of the human monocyte inflammasome by Francisella" . : A306
January 2005 Kim, H-J.; Gavrilin, M. A.; Hart, J. M.; Wewers, M. D.."Tyrosine 82 in CARD domain of caspase-1 negatively regulates caspase-1 activation" . : A335
January 2005 Fahy, R. J.; Yang, L.; Duncan, M. D.; Gavrilin, M. A.; Wewers, M. D.."Monocyte mRNA expression in early septic shock" . : A42

Presentations

"Alpha 1-antitrypsin deficiency - 15 years later." Presented at North American Society of Pediatric Gastroenterology, . (November 1984)

"Pulmonary vascular disorders and sleep apnea." Presented at National Institute of Heath Internal Medicine Board Review Course, . (January 1985)

"Re-establishment of the Anti-Elastase Screen of the Lower Respiratory Tract." Presented at American Thoracic Society, Symposium: Symposium on Alpha 1-antitrypsin Deficiency: From the Gene of the Bedside, . (May 1985)

"Interleukin 1 beta and Sarcoidosis." Presented at American Thoracic Society, Symposium: Sarcoidosis, . (May 1987)

"Pathogenesis of Emphysema: Assessment of Basic Concepts Through Clinical Investigations." Presented at American College of Chest Physicians, Symposium on Alpha 1-antitrypsin Deficiency, . (October 1987)

"Proteases and Their Effect on the Fragile Lung." Presented at American College of Allergy and Immunology, . (November 1988)

"Interleukin 1 beta and the lung." Presented at American Thoracic Society, Symposium: Cytokines and Cytokine Networks in the Lung, . (May 1989)

"Recent Advances in the Treatment of Alpha-1-antitrypsin Deficiency and Future Advances on the Horizon." Presented at American College of Chest Physicians Annual Scientific Meeting, . (October 1989)

"Alpha 1-antitrypsin deficiency: diagnosis and treatment." Presented at Indiana American College of Physicians Annual Meeting, Indianapolis, IN. (January 1989)

"Alveolar Macrophage IL-1 Regulation." Presented at American Thoracic Society International Conference, . (May 1992)

"Role of Alpha-1-antitrypsin in Cystic Fibrosis and Adult Respiratory Distress Syndrome." Presented at American College of Chest Physicians Annual Scientific Meeting, Symposium on New Concepts of Pathogenesis and Treatment of Emphysema, . (October 1993)

"ProIL-1ß Detection by ELISA." Presented at American Physiological Society Conference: Physiology of the Release and Activity of Cytokines, Yale University, . (May 1994)

"New Concepts in IL-1ß Regulation: A receptor antagonist, an ICE inhibitor and a decoy receptor." Presented at American Thoracic Society International Symposium, . (May 1994)

"Pulmonary Vasculitis Update." Presented at Fifth Charleston Lung Symposium, . (March 1994)

"Clinical Implications of alpha-1-antitrypsin Gene Therapy." Presented at International Symposium: Alpha-1-antitrypsin: A World View in 1994, . (October 1994)

"Cytokines in Lung Inflammation." Presented at American Thoracic Society International Conference on Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators, . (May 1995)

"Postgraduate Course: Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators, Cytokines in Airway Inflammation, Lung Injury, Lung Defense." Presented at American Thoracic Society International Conference, . (May 1996)

"Featured Speaker, Advances in Macrophage Biology, Macrophages and IL-1ß: Braking the ICE." Presented at American Thoracic Society International Conference, . (May 1996)

"Role of Antibody in Transplant Vascular Sclerosis." Presented at Second International Symposium on the Etiology and Pathobiology of Transplant Vascular Sclerosis, . (March 1997)

"Caspases: inflammatory and suicidal, State of the Art Lecture." Presented at Midwest American Federation for Medical Research, . (September 1998)

"Cytokines in Lung Inflammation Postgraduate Course 11: Inflammatory Mechanisms in the Lung and Airways: Cells, Cytokines and Mediators." Presented at American Thoracic Society International Conference, . (April 1999)

"Caspases: executioners of apoptosis, Symposium Speaker." Presented at American Thoracic Society International Conference, . (April 1999)

"Macrophages, role of smoking and emphysema." Presented at National Heart Lung and Blood Institute Workshop: Pulmonary Complications of HIV in the Era of HAART, Bethesda, MD. (October 1999)

"Role of epithelium in regulating alveolar macrophage HIV infection." Presented at National Heart Lung and Blood Institute RFA Meeting, Bethesda, MD. (September 2000)

"ICE: on the crossroads of apoptosis and inflammation." Presented at National Institute of Environmental Health Sciences; Research, Research Triangle Park, NC. (October 2000)

"Minisymposium on HIV Infection and the Lung, HIV Interactions with Lung Inflammatory and Parenchymal Cells." Presented at American Thoracic Society International Conference, . (May 2001)

"Macrophages: Link Between Inflammation and Cell Death." Presented at Symposium on Macrophage Biology, American Thoracic Society International Conference, San Francisco, CA. (May 2001)

"Cytokines in Lung Injury, Repair and Inflammation." Presented at American Thoracic Society International Conference, San Francisco, CA. (May 2001)

"New Developments in the Treatment of Sepsis." Presented at OMEN-TV presentation, Columbus, OH. (April 2002)

"CD4 lung lymphocytes predict survival in Asymptomatic HIV Infection." Presented at American Thoracic Society International Conference, Orlando, FL. (May 2004)

"The inflammasome in the host defense response." Presented at Postgraduate Course: Lung innate immunity: the frontlines of host defense, San Francisco, CA. (May 2007)

"Alpha 1-antitrypsin deficiency." Presented at MEDNET webcast, Columbus, OH. (January 2008)

 

Professional Activities

1992 - present Specialized Center of Research Interstitial Lung Disease. NIH.
1994 - present Canadian Cystic Fibrosis Foundation.
1994 - 1995 Veteran's Administration Merit Review Board.
1994 - 1996 American Lung Association, National Grant Review Board.